WebMD offers services to physicians and private clients. In 2013, the Chicago Tribune reported that WebMD, 'has struggled with a fall in advertising revenue with pharmaceutical companies slashing marketing budgets as several blockbuster drugs go off patent.' In response, WebMD began investing in changes to its site in order to entice users who use its site seeking specific information to linger on the site reviewing other material. WebMD is financed by advertising, third-party contributions, and sponsors.

In August 2022, WebMD acquired the leading French medical news site Jim.fr. In 2017, Internet Brands, a company owned by private equity firm Kohlberg Kravis Roberts (KKR) agreed to purchase WebMD Health Corporation for approximately $2.8 billion. The company reported $705 million in revenue for the year 2016. URAC, the Utilization Review Accreditation Commission, has accredited WebMD's operations continuously since 2001 regarding everything from proper disclosures and health content to security and privacy. WebMD is best known as a health information services website, which publishes content regarding health and health care topics, including a symptom checklist, pharmacy information, drugs information, and blogs of physicians with specific topics, and provides a place to store personal medical information. In the first quarter of 2020, WebMD received approximately 127 million unique users viewing over 229 million page views per month.

In the fourth quarter of 2016, WebMD recorded an average of 179.5 million unique users per month, and 3.63 billion page views per quarter. During March 2020, WebMD's network of websites reached more unique visitors each month than any other leading private or government healthcare website, making it the leading health publisher in the United States.

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